E-Sync can be run and installed on Enjay NAS only. It does not sync with any other OS or any other device. 

E-sync transmits data from one device to another device in a compressed and encrypted format.

So, you need Enjay NAS Device to Sync between two sites. However you can use Enjay NAS OS to convert any existing PC into a Storage Device (Enjay NAS)